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The CALIBER study is the latest to report on the efficacy of the LINX procedure

May 22nd, 2019

In the CALIBER study, patients with GERD and moderate-to-severe regurgitation despite eight weeks of treatment with once-daily omeprazole, were randomized to either receive twice-daily doses of the PPI or undergo a minimally invasive procedure with the LINX System. The study found:

  • 89 percent of patients treated with LINX achieved relief from moderate to severe regurgitation compared to 10 percent of patients treated with twice-daily omeprazole (p<0.001) 81 percent of patients treated with LINX achieved >50 percent improvement in GERD-HRQL score (a quality of life measure) compared to 8 percent of patients treated with twice-daily omeprazole (p<0.001)
  • Normal number of reflux episodes was observed in 91 percent of patients treated with LINX compared to 58 percent of twice-daily omeprazole (p<0.001)
  • 81 percent of patients treated with LINX reported satisfaction with their current condition versus 2 percent of patients treated with twice-daily omeprazole

Published in GIE: Gastrointestinal Endoscopy, the peer-reviewed journal of the American Society for Gastrointestinal Endoscopy (ASGE).


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